Is an uncertain result possible, and what would that mean? If youve been diagnosed with DVT or a PE, youll have frequent follow-up appointments so your provider can check treatment progress. Fortunately, about 95 percent of people with this condition never develop a clot, according to the National Institutes of Health. Limitations: You can eat anything you want on your weekly cheat day." Try to build up to 150 minutes of moderate-intensity. Here's what foods they have in common, and how to build a healthy diet when you have factor V Leiden: Advertisement 1. Should people with Factor V Leiden avoid Vitamin K? Factor V Leiden may lead to deep vein thrombosis or a pulmonary embolism, which are serious medical emergencies. This will help to avoid miscarriage or pregnancy complications for the following reasons: . We do not endorse non-Cleveland Clinic products or services. If youre having a deep vein thrombosis or pulmonary embolism, your provider will typically treat you with anticoagulants (blood thinners) and occasionally with thrombolytic (clot-busting) medicines. Some clots do no damage and disappear on their own. There needs to be a balance of these proteins to make sure there is just enough clotting power: Factor V is one of the proteins needed to make blood form clots. If you have this gene mutation, factor V is slow to turn off, and this can create a larger-than-needed clot, which could break off and start traveling through your body. There are many foods that can be beneficial to the health of patients with Factor V Leiden. What about my children?. RTs endorsements. If you have factor V Leiden, there are other ways you can help reduce your risk of developing a blood clot beyond your diet. Factor V and other proteins work together to help your blood clot when necessary. Laboratory testing (blood tests) diagnose this disorder. This can be a life-threatening situation. Please note that medical information found "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. If you know you have the factor V gene mutation, you can work to make your body an inhospitable place for clots, starting with something under your control: your diet. Pasternak, H. The 5-Factor Diet, Ballantine Books, 2009. diabetes.org: "Glycemic Index and Diabetes. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Hormones and birth control pills also increase womens risk of blood clots. No, you cant prevent this blood clotting disorder. 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Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. If you inherited 2 Factor V Leiden genes, you have the homozygous type of Factor V Leiden. Before using birth control pills or hormone therapy for menopause. This is why Factor V Leiden is sometimes called Activated Protein C Resistance and why people with this mutation clot more than those without it. HW}Wc)h"Y$ x N,@I)T7;&?/s"C0]=wSb;{PlYdA&Trb"agbH0Hok8bio@k'q One of these factors is Factor V (FV) Leiden (rs6025), which is a missense variant caused by a single nucleotide polymorphism (SNP) in the F5 gene. Your body has many different proteins that do this work. (accessed March 04, 2023). Deficiencies of antithrombin and proteins C/S, elevated fibrinogen levels, and other clotting disorders also raise risk. All rights reserved. Some people do not have the normal Factor V protein. The prevalence of factor V Leiden varies by ethnicity. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017. How does prothrombin gene mutation affect my body? Here's some information to help you prepare for your appointment. It does not increase the risk of myocardial infarction (heart attacks) or arterial strokes. You have 1 Factor V Leiden gene from one parent and 1 normal Factor V gene from your other parent. Do I need to take medication to prevent additional blood clots? Fruits and vegetables: Get at least five servings of fruits and veggies throughout the day, and incorporate all different kinds. Miscarriages associated with factor V Leiden are more likely to occur later in pregnancy (after the first trimester). All rights reserved. Lean protein: Prioritize lean proteins such as chicken, turkey and lean beef. The best diet to follow is one full of foods that support heart health, because these are also naturally good for your blood health. 0000236831 00000 n People who have inherited factor V Leiden from only one parent have a 5 percent chance of developing an abnormal blood clot by age 65. There is also a 50% chance that your child will inherit your normal Factor V gene. If you inherited 1 Factor V Leiden gene from one parent, you have the heterozygous type of Factor V Leiden. https://www.news-medical.net/health/Anticoagulant-Food-Drug-Interactions.aspx. The condition it self does not require a special diet. Factor V Leiden (pronounced factor five) is the most common hereditary clotting disorder in the United States, present in 2 percent to 7 percent of Caucasians, less often in Hispanics and. It is advised that vitamin K intake through diet (chiefly through liver meats, high amounts of green leafy vegetables, and cranberry juice) also be closely monitored in such patients for the same reason. Doctors generally prescribe blood-thinning medications to treat people who develop abnormal blood clots. New York, N.Y.: McGraw-Hill Education; 2016. https://accessmedicine.mhmedical.com. The normal blood clotting process goes to work right away when you get a cut platelets rush to the site to seal it, and a substance called fibrin aided by factor V helps the platelets to form a clot. How frequently do I need to have checkups. Yes, you may be able to donate blood if youre not taking a blood thinner. U.S. National Institutes of Health, National Library of Medicine. In a worst-case scenario, it lands in your legs, leading to deep vein thrombosis, or your lungs, forming a pulmonary embolism. The weight loss and increased activity that The 5-Factor Diet promises are key to the prevention and treatment of many conditions, including heart disease, high blood pressure, and diabetes. Heart-healthy foods help reduce inflammation and may help you get to a healthy weight, both of which are necessary for healthy blood, per Johns Hopkins Medicine. Its the most common blood clotting disorder thats inherited, or passed down within biological families. Owned and operated by AZoNetwork, 2000-2023. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Following your providers guidance can help you catch and resolve problems early before they interrupt the flow of your life. Have had clots two or more different times in the past. But theres no clear consensus, and researchers continue to explore what risks, if any, factor V Leiden poses during pregnancy. But some people inherit mutated versions of this gene and develop a condition called factor V Leiden thrombophilia. Want to talk about Multiple Myeloma: Anyone else? Accessed June 4, 2018. Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. Both of those types of injectable blood thinners are safe for your baby. Mango and St. Johns wort are also clinically relevant inhibitors of VKAs. Do you have any brochures or other printed material that I can take with me? It is not a disease. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://medlineplus.gov/genetics/condition/prothrombin-thrombophilia/#resources). Direct oral anticoagulants (DOACs) are expected to replace VKAs because of their increased safety margin. 2019. This site complies with the HONcode standard for trustworthy health information: verify here. 0000006722 00000 n There are 2 copies for Factor V gene, which are passed down from our parents. Cranberry products are not significant unless taken in high amounts, as for urinary infections. According to NutritionData, the best sources of folate per 100 g serving are: Beans and lentils (~50% RDI) Raw spinach (49% RDI) Asparagus (37% RDI) Romaine (Cos) lettuce (34% RDI) Broccoli (27% RDI) Avocado (20% RDI) Oranges/Mangoes (~10% RDI) Factor V Leiden and prothrombin gene mutations cause about 50% of inherited coagulopathies. New York, N.Y.: McGraw-Hill Education; 2016. https://accessmedicine.mhmedical.com. Accessed June 4, 2018. Does It Allow for Dietary Restrictions or Preferences? Make a donation. Factor V Leiden is an inherited blood clotting disorder that raises your risk of deep vein thrombosis or a pulmonary embolism. Inherited thrombophilias in pregnancy. Deep venous thrombosis (DVT). This change causes factor V to resist the actions of other proteins (protein C and protein S), which normally inactivate factor V when needed to keep your blood from clotting abnormally. You won't go hungry on The 5-Factor Diet. Want to talk about Multiple Myeloma: Anyone else? The plan does not address the differences in calorie needs of each individual. Zoppi, Lois. Since then I was also diagnosed w My name is MARTIN R. LEMIEUX, and for over 20 years now Ive survived five DVTS BLOOD CLOTS in my left leg, one clot in my right leg, and another clot in my left pelvic area. Factor V Leiden resists the effects of Activated Protein C, so it takes longer to turn off Factor V Leiden. The prothrombin gene mutation can make you more likely to get harmful blood clots, but you may never get one. It increases the chances that your blood will form abnormal blood clots that can be dangerous. Women who carry the factor V Leiden mutation may have an increased tendency to develop blood clots during pregnancy or when taking the hormone estrogen. Blood clots can cause serious problems in your body when they block blood flow, keeping oxygen from getting to your cells. .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits span{color: #ffffff;}.wpcdt-timer-24806 .wpcdt-clock{max-width: 640px;}, Carol McIntosh of Caroga Lake, New York was 32 when she was diagnosed with her first incident of deep vein, March is Blood Clot Awareness Month (BCAM), a time dedicated to spreading the word about blood clots and their potentially. This site complies with the HONcode standard for trustworthy health information: verify here. The latest information about heart & vascular disorders, treatments, tests and prevention from the No. Learn more about symptoms, risk factors, causes, diagnosis, treatment, complications, and outlook . About 1 in every 50 white people in Europe and North America has the heterozygous prothrombin gene mutation, making it the second most common inherited clotting disorder. A single copy of these materials may be reprinted for noncommercial personal use only. In most people, a protein called activated protein C regulates the activity of . The Top 5 Worst Foods for Your Heart, According to a Dietitian. In 2010 I was pregnant with my son. An INR value of 1.1 or below is considered normal in healthy patients, with lower values indicating faster clotting, while higher values show slower clotting rate. As they come, write them down. It may ease your mind to know that most people with this disorder never have a blood clot. . Gluten-free: The breads Pasternak allows are flour-free. (https://www.stoptheclot.org/learn_more/prothrombin-g20210a-factor-ii-mutation-links/), (https://www.merckmanuals.com/home/blood-disorders/excessive-clotting/excessive-clotting?query=prothrombin%20gene%20mutation). .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits, 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). 0000006951 00000 n